Version 5.4
Mus musculus Protein: Apoe
Summary
InnateDB Protein IDBP-624091.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apoe
Protein Name apolipoprotein E
Synonyms AI255918;
Species Mus musculus
Ensembl Protein ENSMUSP00000133359
InnateDB Gene IDBG-152108 (Apoe)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008201 heparin binding
GO:0008289 lipid binding
GO:0016209 antioxidant activity
GO:0017127 cholesterol transporter activity
GO:0042803 protein homodimerization activity
GO:0046848 hydroxyapatite binding
GO:0046911 metal chelating activity
GO:0046982 protein heterodimerization activity
GO:0048156 tau protein binding
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070326 very-low-density lipoprotein particle receptor binding
GO:0071813 lipoprotein particle binding
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002021 response to dietary excess
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006707 cholesterol catabolic process
GO:0006869 lipid transport
GO:0006874 cellular calcium ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0006979 response to oxidative stress
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0007568 aging
GO:0008203 cholesterol metabolic process
GO:0010468 regulation of gene expression
GO:0010544 negative regulation of platelet activation
GO:0010873 positive regulation of cholesterol esterification
GO:0010875 positive regulation of cholesterol efflux
GO:0019934 cGMP-mediated signaling
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0032526 response to retinoic acid
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0032868 response to insulin
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034380 high-density lipoprotein particle assembly
GO:0034382 chylomicron remnant clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0034447 very-low-density lipoprotein particle clearance
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042159 lipoprotein catabolic process
GO:0042311 vasodilation
GO:0042632 cholesterol homeostasis
GO:0043407 negative regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043691 reverse cholesterol transport
GO:0045471 response to ethanol
GO:0045541 negative regulation of cholesterol biosynthetic process
GO:0045773 positive regulation of axon extension
GO:0048709 oligodendrocyte differentiation
GO:0048844 artery morphogenesis
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051651 maintenance of location in cell
GO:0055088 lipid homeostasis
GO:0071347 cellular response to interleukin-1
GO:0071363 cellular response to growth factor stimulus
GO:0071397 cellular response to cholesterol
GO:0072358 cardiovascular system development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0030425 dendrite
GO:0031232 extrinsic component of external side of plasma membrane
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0042627 chylomicron
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID MGI:88057
InterPro IPR000074 Apolipoprotein A1/A4/E
PFAM PF01442
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8C6E4
UniProt Splice Variant
Entrez Gene 11816
UniGene Mm.468917
RefSeq
MGI ID
MGI Symbol Apoe
OMIM
CCDS
HPRD
IMGT
EMBL AC149282 AK075843
GenPept BAC36000

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca