Version 5.4
Mus musculus Protein: Apoe
Summary
InnateDB Protein IDBP-624093.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apoe
Protein Name apolipoprotein E
Synonyms AI255918;
Species Mus musculus
Ensembl Protein ENSMUSP00000134558
InnateDB Gene IDBG-152108 (Apoe)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0017127 cholesterol transporter activity
GO:0071813 lipoprotein particle binding
Biological Process
GO:0002021 response to dietary excess
GO:0006629 lipid metabolic process
GO:0006707 cholesterol catabolic process
GO:0006869 lipid transport
GO:0006874 cellular calcium ion homeostasis
GO:0006979 response to oxidative stress
GO:0008203 cholesterol metabolic process
GO:0010468 regulation of gene expression
GO:0033344 cholesterol efflux
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042159 lipoprotein catabolic process
GO:0042311 vasodilation
GO:0042632 cholesterol homeostasis
GO:0048844 artery morphogenesis
GO:0051651 maintenance of location in cell
GO:0055088 lipid homeostasis
GO:0072358 cardiovascular system development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:88057
InterPro IPR000074 Apolipoprotein A1/A4/E
PFAM PF01442
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3UZM8
UniProt Splice Variant
Entrez Gene 11816
UniGene Mm.468917
RefSeq
MGI ID
MGI Symbol Apoe
OMIM
CCDS
HPRD
IMGT
EMBL AC149282
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca