InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lamb1

Summary

InnateDB Protein

IDBP-624289.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lamb1

Protein Name

laminin B1

Synonyms

C77966; C80098; C81607; D130003D08Rik; Lamb-1; Lamb1-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132778

InnateDB Gene

IDBG-132841 (Lamb1)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex (By similarity). It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons (By similarity). Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Disease Associations

Tissue Specificity

Widely expressed in the embryo. High levels are detected in the cerebellar basement membrane, at postnatal day 7. {ECO:0000269PubMed:23472759}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0043208	glycosphingolipid binding

Biological Process

GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007566	embryo implantation
GO:0007611	learning or memory
GO:0016477	cell migration
GO:0030335	positive regulation of cell migration
GO:0031175	neuron projection development
GO:0042476	odontogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005606	laminin-1 complex
GO:0005607	laminin-2 complex
GO:0043256	laminin complex
GO:0043257	laminin-8 complex
GO:0043259	laminin-10 complex
GO:0048471	perinuclear region of cytoplasm