Version 5.4
Mus musculus Protein: Lep
Summary
InnateDB Protein IDBP-624636.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lep
Protein Name leptin
Synonyms ob; obese;
Species Mus musculus
Ensembl Protein ENSMUSP00000130087
InnateDB Gene IDBG-130781 (Lep)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0051428 peptide hormone receptor binding
Biological Process
GO:0001542 ovulation from ovarian follicle
GO:0001666 response to hypoxia
GO:0001819 positive regulation of cytokine production
GO:0001890 placenta development
GO:0002021 response to dietary excess
GO:0006006 glucose metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006112 energy reserve metabolic process
GO:0006114 glycerol biosynthetic process
GO:0006629 lipid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0007165 signal transduction
GO:0007565 female pregnancy
GO:0007623 circadian rhythm
GO:0008203 cholesterol metabolic process
GO:0008206 bile acid metabolic process
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell proliferation
GO:0009892 negative regulation of metabolic process
GO:0019222 regulation of metabolic process
GO:0021954 central nervous system neuron development
GO:0030073 insulin secretion
GO:0030300 regulation of intestinal cholesterol absorption
GO:0032868 response to insulin
GO:0033197 response to vitamin E
GO:0033210 leptin-mediated signaling pathway
GO:0033686 positive regulation of luteinizing hormone secretion
GO:0035630 bone mineralization involved in bone maturation
GO:0042445 hormone metabolic process
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0043066 negative regulation of apoptotic process
GO:0043270 positive regulation of ion transport
GO:0043410 positive regulation of MAPK cascade
GO:0045598 regulation of fat cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045906 negative regulation of vasoconstriction
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0048639 positive regulation of developmental growth
GO:0050796 regulation of insulin secretion
GO:0050810 regulation of steroid biosynthetic process
GO:0050901 leukocyte tethering or rolling
GO:0060587 regulation of lipoprotein lipid oxidation
GO:0060612 adipose tissue development
GO:0061037 negative regulation of cartilage development
GO:0071298 cellular response to L-ascorbic acid
GO:0071300 cellular response to retinoic acid
GO:2000486 negative regulation of glutamine transport
GO:2000491 positive regulation of hepatic stellate cell activation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:104663
InterPro IPR000065 Obesity factor
IPR009079 Four-helical cytokine-like, core
PFAM PF02024
PRINTS PR00495
PIRSF PIRSF001837
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q7Z0
UniProt Splice Variant
Entrez Gene 16846
UniGene Mm.277072
RefSeq
MGI ID
MGI Symbol Lep
OMIM
CCDS
HPRD
IMGT
EMBL AC072048
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca