Version 5.4
Mus musculus Protein: Parg
Summary
InnateDB Protein IDBP-624850.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Parg
Protein Name poly (ADP-ribose) glycohydrolase
Synonyms AI413217;
Species Mus musculus
Ensembl Protein ENSMUSP00000131566
InnateDB Gene IDBG-147524 (Parg)
Protein Structure
UniProt Annotation
Function Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Colocalizes with PCNA at replication foci. Relocalizes to the cytoplasm in response to DNA damage (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004649 poly(ADP-ribose) glycohydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008152 metabolic process
GO:0016045 detection of bacterium
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1347094
InterPro IPR007724 Poly(ADP-ribose) glycohydrolase
PFAM PF05028
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88622
PhosphoSite PhosphoSite-O88622
TrEMBL E9Q954
UniProt Splice Variant
Entrez Gene 26430
UniGene Mm.473227
RefSeq
MGI ID 4NA6
MGI Symbol Parg
OMIM
CCDS
HPRD
IMGT
EMBL AC154532 AC167565 AF079557 AK036656 BC050892 BC059827
GenPept AAC28735 BAC29519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca