InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Csrp3

Summary

InnateDB Protein

IDBP-624989.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Csrp3

Protein Name

cysteine and glycine-rich protein 3

Synonyms

CRP3; MLP; MMLP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129378

InnateDB Gene

IDBG-187675 (Csrp3)

Protein Structure

UniProt Annotation

Function

Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. {ECO:0000269PubMed:15665106, ECO:0000269PubMed:9039266}.

Subcellular Localization

Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:18258855}. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269PubMed:18258855}. Note=Mainly cytoplasmic. In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (via C-terminus). {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008307	structural constituent of muscle
GO:0031433	telethonin binding
GO:0042805	actinin binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0003300	cardiac muscle hypertrophy
GO:0006874	cellular calcium ion homeostasis
GO:0007517	muscle organ development
GO:0033365	protein localization to organelle
GO:0035995	detection of muscle stretch
GO:0048738	cardiac muscle tissue development
GO:0055003	cardiac myofibril assembly
GO:0060048	cardiac muscle contraction