Version 5.4
Mus musculus Protein: Wapal
Summary
InnateDB Protein IDBP-625035.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wapal
Protein Name wings apart-like homolog (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000130547
InnateDB Gene IDBG-150449 (Wapal)
Protein Structure
UniProt Annotation
Function Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in large pachytene spermatocytes of testis. Down-regulated by dioxin in testis. {ECO:0000269PubMed:15620708}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0008156 negative regulation of DNA replication
GO:0009636 response to toxic substance
GO:0035562 negative regulation of chromatin binding
GO:0045875 negative regulation of sister chromatid cohesion
GO:0048146 positive regulation of fibroblast proliferation
GO:0051983 regulation of chromosome segregation
GO:0060623 regulation of chromosome condensation
GO:0071168 protein localization to chromatin
GO:0071922 regulation of cohesin localization to chromatin
Cellular Component
GO:0000785 chromatin
GO:0000795 synaptonemal complex
GO:0005737 cytoplasm
GO:0008278 cohesin complex
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID MGI:2675859
InterPro IPR016024 Armadillo-type fold
IPR022771 Wings apart-like protein
PFAM PF07814
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q65Z40
PhosphoSite PhosphoSite-Q65Z40
TrEMBL
UniProt Splice Variant
Entrez Gene 218914
UniGene Mm.489820
RefSeq
MGI ID
MGI Symbol Wapal
OMIM
CCDS CCDS36880
HPRD
IMGT
EMBL AB167349 AK129105 BC139434
GenPept AAI39435 BAC97915 BAD44717

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca