Version 5.4
Mus musculus Protein: Mis12
Summary
InnateDB Protein IDBP-625242.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mis12
Protein Name MIS12 homolog (yeast)
Synonyms 2510025F08Rik; AU044651; Misc12;
Species Mus musculus
Ensembl Protein ENSMUSP00000127782
InnateDB Gene IDBG-195870 (Mis12)
Protein Structure
UniProt Annotation
Function Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. {ECO:0000250}.
Subcellular Localization Nucleus. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Associated with the kinetochore. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0051382 kinetochore assembly
Cellular Component
GO:0000444 MIS12/MIND type complex
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1914389
InterPro IPR008685 Centromere protein Mis12
PFAM PF05859
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CY25
PhosphoSite PhosphoSite-Q9CY25
TrEMBL
UniProt Splice Variant
Entrez Gene 67139
UniGene Mm.475587
RefSeq XP_006534032
MGI ID
MGI Symbol Mis12
OMIM
CCDS CCDS24973
HPRD
IMGT
EMBL AK010995 AK132010 AK139957 AK154531 AL596136 BC026790
GenPept AAH26790 BAB27314 BAE20937 BAE24195 BAE32656 CAI26070 CAI26071 CAI26072 CAI26073

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca