InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cic

Summary

InnateDB Protein

IDBP-625617.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cic

Protein Name

capicua homolog (Drosophila)

Synonyms

1200010B10Rik; mKIAA0306;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126659

InnateDB Gene

IDBG-156740 (Cic)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor which may play a role in development of the central nervous system (CNS). {ECO:0000269PubMed:17190598}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are present in cerebellum (at protein level). {ECO:0000269PubMed:17190598}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1918972

InterPro

IPR009071 High mobility group box domain

PFAM

PF00505
PF09011

PRINTS

PIRSF

SMART

SM00398

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q924A2

PhosphoSite

PhosphoSite-Q924A2

TrEMBL

UniProt Splice Variant

Entrez Gene

71722

UniGene

Mm.484854

RefSeq

NP_082158

MGI ID

MGI Symbol

Cic

OMIM

CCDS

CCDS52146

HPRD

IMGT

EMBL

AB093224 AC156992 AF363690 AK004685 AK147276 AK147535 BC040463 BC058665

GenPept

AAH40463 AAH58665 AAK73516 BAB23472 BAC41408 BAE27813 BAE27978