Version 5.4
Mus musculus Protein: Eif4b
Summary
InnateDB Protein IDBP-625652.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif4b
Protein Name eukaryotic translation initiation factor 4B
Synonyms 2310046H11Rik; AL024095; C85189; Eif4a2;
Species Mus musculus
Ensembl Protein ENSMUSP00000127774
InnateDB Gene IDBG-187457 (Eif4b)
Protein Structure
UniProt Annotation
Function Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
Protein Structure and Domains
PDB ID MGI:95304
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGD9
PhosphoSite PhosphoSite-Q8BGD9
TrEMBL Q922K6
UniProt Splice Variant
Entrez Gene 75705
UniGene Mm.427880
RefSeq NP_663600
MGI ID
MGI Symbol Eif4b
OMIM
CCDS CCDS49737
HPRD
IMGT
EMBL AK045250 AK077423 AK170354 BC007171 BC147746 BC147748
GenPept AAH07171 AAI47747 AAI47749 BAC32280 BAC36793 BAE41740

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca