InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MSRB2

Summary

InnateDB Protein

IDBP-62572.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSRB2

Protein Name

methionine sulfoxide reductase B2

Synonyms

CBS-1; CBS1; MSRB; PILB;

Species

Homo sapiens

Ensembl Protein

ENSP00000365693

InnateDB Gene

IDBG-62566 (MSRB2)

Protein Structure

UniProt Annotation

Function

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. {ECO:0000269PubMed:18424444}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:18424444}.

Disease Associations

Tissue Specificity

Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate. {ECO:0000269PubMed:10375640, ECO:0000269PubMed:15914630}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003779	actin binding
GO:0008270	zinc ion binding
GO:0033743	peptide-methionine (R)-S-oxide reductase activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006979	response to oxidative stress
GO:0030041	actin filament polymerization
GO:0030091	protein repair
GO:0055114	oxidation-reduction process