Version 5.4
Mus musculus Protein: Iqsec2
Summary
InnateDB Protein IDBP-625820.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Iqsec2
Protein Name IQ motif and Sec7 domain 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000127249
InnateDB Gene IDBG-180098 (Iqsec2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0030054 cell junction
Protein Structure and Domains
PDB ID MGI:3528396
InterPro IPR000048 IQ motif, EF-hand binding site
IPR000904 Sec7 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00612
PF01369
PRINTS
PIRSF
SMART SM00015
SM00222
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-NP_001108136
TrEMBL A4GZ26
UniProt Splice Variant
Entrez Gene 245666
UniGene Mm.395684
RefSeq NP_001108136
MGI ID
MGI Symbol Iqsec2
OMIM
CCDS CCDS53224
HPRD
IMGT
EMBL AB275281 AC083816
GenPept BAF49453

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca