Version 5.4
Mus musculus Protein: Map4k5
Summary
InnateDB Protein IDBP-625947.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Map4k5
Protein Name mitogen-activated protein kinase kinase kinase kinase 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000126006
InnateDB Gene IDBG-144865 (Map4k5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005524 ATP binding
GO:0008349 MAP kinase kinase kinase kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0000185 activation of MAPKKK activity
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1925503
InterPro IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF00780
PF07714
PRINTS PR00109
PIRSF
SMART SM00036
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q1T3
UniProt Splice Variant
Entrez Gene 399510
UniGene Mm.413430
RefSeq
MGI ID
MGI Symbol Map4k5
OMIM
CCDS
HPRD
IMGT
EMBL AC141560 AC166827
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca