InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hivep3

Summary

InnateDB Protein

IDBP-625961.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hivep3

Protein Name

human immunodeficiency virus type I enhancer binding protein 3

Synonyms

2900056N03Rik; A130075N07; AI848000; E030045D18Rik; KBP-1; KBP1; Krc; Rc; Schnurri-3; Shn3; Zas3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130249

InnateDB Gene

IDBG-183408 (Hivep3)

Protein Structure

UniProt Annotation

Function

Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down- regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269PubMed:10625627, ECO:0000269PubMed:11035930, ECO:0000269PubMed:11804591, ECO:0000269PubMed:12001065, ECO:0000269PubMed:12193271, ECO:0000269PubMed:14530385, ECO:0000269PubMed:14707112, ECO:0000269PubMed:8255760, ECO:0000269PubMed:8812474}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11804591}. Nucleus {ECO:0000269PubMed:11804591}.

Disease Associations

Tissue Specificity

Expressed in macrophages, lymphocytes, brain, thymus, spleen and bone marrow. Expressed in osteoblasts, whole bone and, to a lesser extend, in osteoclasts. {ECO:0000269PubMed:14530385, ECO:0000269PubMed:16728642, ECO:0000269PubMed:8255760, ECO:0000269PubMed:8812474}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0035914	skeletal muscle cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:106589

InterPro

IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like

PFAM

PF00096

PRINTS

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2A884

PhosphoSite

PhosphoSite-A2A884

TrEMBL

Q3UTY2

UniProt Splice Variant

Entrez Gene

16656

UniGene

Mm.401280

RefSeq

MGI ID

MGI Symbol

Hivep3

OMIM

CCDS

CCDS38863

HPRD

IMGT

EMBL

AK138988 AK173200 AL607142 AY454345 L07911

GenPept

AAA40039 AAR88090 BAD32478 BAE23848 CAM27499