InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mecp2

Summary

InnateDB Protein

IDBP-625981.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mecp2

Protein Name

methyl CpG binding protein 2

Synonyms

1500041B07Rik; D630021H01Rik; Mbd5; WBP10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127115

InnateDB Gene

IDBG-154983 (Mecp2)

Protein Structure

UniProt Annotation

Function

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000269PubMed:23434322}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15034150, ECO:0000269PubMed:17296936}. Note=Colocalized with methyl-CpG in the genome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008327	methyl-CpG binding
GO:0010385	double-stranded methylated DNA binding
GO:0019904	protein domain specific binding
GO:0035197	siRNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0001662	behavioral fear response
GO:0001666	response to hypoxia
GO:0001964	startle response
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0006020	inositol metabolic process
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c
GO:0006342	chromatin silencing
GO:0006349	regulation of gene expression by genetic imprinting
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006541	glutamine metabolic process
GO:0006576	cellular biogenic amine metabolic process
GO:0007268	synaptic transmission
GO:0007416	synapse assembly
GO:0007420	brain development
GO:0007585	respiratory gaseous exchange
GO:0007612	learning
GO:0007613	memory
GO:0007616	long-term memory
GO:0008104	protein localization
GO:0008211	glucocorticoid metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0008344	adult locomotory behavior
GO:0008542	visual learning
GO:0009405	pathogenesis
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0016358	dendrite development
GO:0016571	histone methylation
GO:0016573	histone acetylation
GO:0019230	proprioception
GO:0019233	sensory perception of pain
GO:0021549	cerebellum development
GO:0021591	ventricular system development
GO:0030182	neuron differentiation
GO:0031061	negative regulation of histone methylation
GO:0031175	neuron projection development
GO:0032048	cardiolipin metabolic process
GO:0033555	multicellular organismal response to stress
GO:0035067	negative regulation of histone acetylation
GO:0035176	social behavior
GO:0040029	regulation of gene expression, epigenetic
GO:0042551	neuron maturation
GO:0043524	negative regulation of neuron apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046470	phosphatidylcholine metabolic process
GO:0048167	regulation of synaptic plasticity
GO:0050432	catecholamine secretion
GO:0050884	neuromuscular process controlling posture
GO:0050905	neuromuscular process
GO:0051965	positive regulation of synapse assembly
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060291	long-term synaptic potentiation