InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hrh3

Summary

InnateDB Protein

IDBP-626179.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hrh3

Protein Name

histamine receptor H3

Synonyms

AW049250; H3R; HH3R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132203

InnateDB Gene

IDBG-213755 (Hrh3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity
GO:0008144	drug binding

Biological Process

GO:0001505	regulation of neurotransmitter levels
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007420	brain development
GO:0007612	learning
GO:0007613	memory
GO:0014050	negative regulation of glutamate secretion
GO:0014053	negative regulation of gamma-aminobutyric acid secretion
GO:0014061	regulation of norepinephrine secretion
GO:0014063	negative regulation of serotonin secretion
GO:0014070	response to organic cyclic compound
GO:0042755	eating behavior
GO:0042756	drinking behavior
GO:0045776	negative regulation of blood pressure
GO:0050679	positive regulation of epithelial cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043209	myelin sheath

Protein Structure and Domains

PDB ID

MGI:2139279

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000995 Muscarinic acetylcholine receptor family
IPR003980 Histamine H3 receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00243
PR01471

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite