InnateDB Protein
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IDBP-62623.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PTH2
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Protein Name
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parathyroid hormone 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000270631
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InnateDB Gene
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IDBG-62621 (PTH2)
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Protein Structure
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Function |
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. {ECO:0000269PubMed:11861531, ECO:0000269PubMed:12559132, ECO:0000269PubMed:12754053, ECO:0000269PubMed:14988434}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart. {ECO:0000269PubMed:12098667}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96A98
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
113091
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UniGene |
Hs.339845
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RefSeq |
NP_848544
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HUGO |
HGNC:30828
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OMIM |
608386
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CCDS |
CCDS12763
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HPRD |
16328
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IMGT |
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EMBL |
AY037555
AY048588
BC093995
BC093997
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GenPept |
AAH93995
AAH93997
AAK68689
AAL06597
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