Version 5.4
Homo sapiens Protein: PTH2
Summary
InnateDB Protein IDBP-62623.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTH2
Protein Name parathyroid hormone 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000270631
InnateDB Gene IDBG-62621 (PTH2)
Protein Structure
UniProt Annotation
Function Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. {ECO:0000269PubMed:11861531, ECO:0000269PubMed:12559132, ECO:0000269PubMed:12754053, ECO:0000269PubMed:14988434}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart. {ECO:0000269PubMed:12098667}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96A98
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 113091
UniGene Hs.339845
RefSeq NP_848544
HUGO HGNC:30828
OMIM 608386
CCDS CCDS12763
HPRD 16328
IMGT
EMBL AY037555 AY048588 BC093995 BC093997
GenPept AAH93995 AAH93997 AAK68689 AAL06597

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca