Version 5.4
Mus musculus Protein: Fan1
Summary
InnateDB Protein IDBP-626242.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fan1
Protein Name FANCD2/FANCI-associated nuclease 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000130012
InnateDB Gene IDBG-191028 (Fan1)
Protein Structure
UniProt Annotation
Function Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap- specific enzymes to unhook the ICL by cleaving the lagging-strand template (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004528 phosphodiesterase I activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0033683 nucleotide-excision repair, DNA incision
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:3045266
InterPro IPR014883 VRR-NUC domain
PFAM PF08774
PRINTS
PIRSF
SMART SM00990
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q69ZT1
PhosphoSite PhosphoSite-Q69ZT1
TrEMBL
UniProt Splice Variant
Entrez Gene 330554
UniGene Mm.236510
RefSeq NP_808561
MGI ID
MGI Symbol Fan1
OMIM
CCDS CCDS52265
HPRD
IMGT
EMBL AC129199 AC139849 AK077918 AK173087 BC116270 BC116271
GenPept AAI16271 AAI16272 BAC37062 BAD32365

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca