InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pirt

Summary

InnateDB Protein

IDBP-626254.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pirt

Protein Name

phosphoinositide-interacting regulator of transient receptor potential channels

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128117

InnateDB Gene

IDBG-186896 (Pirt)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5- bisphosphate (PIP2), but not phosphatidylinositol (PI). {ECO:0000269PubMed:18455988}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Strongly expressed in most dorsal root ganglia (DRG) and trigeminal neurons. Expressed by most peptidergic (CGRP+) and non-peptidergic (IB4+) DRG neurons. Weakly expressed in other parts of the peripheral nervous system (PNS) including sympathetic and enteric neurons. Not expressed in the spinal cord. {ECO:0000269PubMed:18455988}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

Cellular Component

GO:0016021

integral component of membrane