InnateDB Protein
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IDBP-626313.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gpr81
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Protein Name
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G protein-coupled receptor 81
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000129280
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InnateDB Gene
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IDBG-200080 (Gpr81)
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Protein Structure
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Function |
Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway. {ECO:0000269PubMed:18174606, ECO:0000269PubMed:19047060}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Highly expressed in subcutaneous fat and omental fat and detectable in lower levels in brain and many other tissues. High levels detected in epididymal and subcutaneous fat with slightly lower in omental fat, low levels are detected in the brain, skeletal muscle, kidney, liver and the pancreas (at protein level). {ECO:0000269PubMed:18174606, ECO:0000269PubMed:19047060}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0004930
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G-protein coupled receptor activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2441671
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InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR017452
GPCR, rhodopsin-like, 7TM
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PFAM |
PF00001
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PRINTS |
PR00237
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C131
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PhosphoSite |
PhosphoSite-Q8C131
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TrEMBL |
E9PZR8
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UniProt Splice Variant |
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Entrez Gene |
243270
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UniGene |
Mm.416403
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RefSeq |
NP_780729
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MGI ID |
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MGI Symbol |
Hcar1
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OMIM |
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CCDS |
CCDS19669
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HPRD |
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IMGT |
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EMBL |
AC122753
AC129582
AK029064
BC141305
EU809460
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GenPept |
AAI41306
ACJ03846
BAC26273
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