InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pparg

Summary

InnateDB Protein

IDBP-626496.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pparg

Protein Name

peroxisome proliferator activated receptor gamma

Synonyms

Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma; PPARgamma2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131962

InnateDB Gene

IDBG-179253 (Pparg)

Protein Structure

UniProt Annotation

Function

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. {ECO:0000269PubMed:18719582, ECO:0000269PubMed:21035761, ECO:0000269PubMed:21994940, ECO:0000269PubMed:23525231}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407, ECO:0000269PubMed:20498072, ECO:0000269PubMed:23525231}. Cytoplasm {ECO:0000250}. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner (By similarity). CCRN4L/NOC enhances its nuclear translocation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest expression in white and brown adipose tissue. Also found in liver, skeletal muscle, heart, adrenal gland, spleen, kidney and intestine. Isoform 2 is more abundant than isoform 1 in adipose tissue. {ECO:0000269PubMed:21035761, ECO:0000269PubMed:7838715}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	32 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	104 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:97747

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003074 Peroxisome proliferator-activated receptor
IPR003077 Peroxisome proliferator-activated receptor, gamma
IPR008946 Nuclear hormone receptor, ligand-binding
IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal

PFAM

PF00104
PF00105
PF12577

PRINTS

PR00047
PR00398
PR01288
PR01291

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt