Version 5.4
Mus musculus Protein: Zyx
Summary
InnateDB Protein IDBP-626938.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zyx
Protein Name zyxin
Synonyms 9530098H06Rik; R75157;
Species Mus musculus
Ensembl Protein ENSMUSP00000126622
InnateDB Gene IDBG-141978 (Zyx)
Protein Structure
UniProt Annotation
Function Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1 (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 59 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007155 cell adhesion
GO:0050727 regulation of inflammatory response
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005913 cell-cell adherens junction
GO:0005925 focal adhesion
Protein Structure and Domains
PDB ID MGI:103072
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62523
PhosphoSite PhosphoSite-Q62523
TrEMBL Q8CD55
UniProt Splice Variant
Entrez Gene 22793
UniGene Mm.282303
RefSeq NP_001276546
MGI ID
MGI Symbol Zyx
OMIM
CCDS CCDS20066
HPRD
IMGT
EMBL AK031415 AK147812 CH466533 X99063 Y07711
GenPept BAC27394 BAE28154 CAA67510 CAA68984 EDL13482

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca