Version 5.4
Mus musculus Protein: Cyb5r1
Summary
InnateDB Protein IDBP-627559.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyb5r1
Protein Name cytochrome b5 reductase 1
Synonyms 1500005G05Rik; B5R.1; C80155; Nqo3a2;
Species Mus musculus
Ensembl Protein ENSMUSP00000133385
InnateDB Gene IDBG-193696 (Cyb5r1)
Protein Structure
UniProt Annotation
Function NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0016491 oxidoreductase activity
Biological Process
GO:0016126 sterol biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1919267
InterPro IPR001834 NADH:cytochrome b5 reductase (CBR)
IPR008333 Oxidoreductase, FAD-binding domain
IPR017938 Riboflavin synthase-like beta-barrel
PFAM PF00970
PRINTS PR00406
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DB73
PhosphoSite PhosphoSite-Q9DB73
TrEMBL
UniProt Splice Variant
Entrez Gene 72017
UniGene Mm.490981
RefSeq
MGI ID
MGI Symbol Cyb5r1
OMIM
CCDS
HPRD
IMGT
EMBL AK005159 AK159663 AK167178 BC016266 BC024618
GenPept AAH16266 AAH24618 BAB23850 BAE35270 BAE39313

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca