Version 5.4
Mus musculus Protein: Rdbp
Summary
InnateDB Protein IDBP-627785.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rdbp
Protein Name RD RNA-binding protein
Synonyms D17H6S45; NELF-E; RD; Rdbp;
Species Mus musculus
Ensembl Protein ENSMUSP00000131195
InnateDB Gene IDBG-174471 (Rdbp)
Protein Structure
UniProt Annotation
Function Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
Cellular Component
GO:0005739 mitochondrion
GO:0032021 NELF complex
Protein Structure and Domains
PDB ID MGI:102744
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P19426
PhosphoSite PhosphoSite-P19426
TrEMBL Q3UIA1
UniProt Splice Variant
Entrez Gene 27632
UniGene Mm.279907
RefSeq NP_613046
MGI ID
MGI Symbol Nelfe
OMIM
CCDS CCDS28662
HPRD
IMGT
EMBL AF109906 AK012389 AK131947 AK147011 BC034867 CT025759 M21332 U83841 U83842
GenPept AAA39680 AAB41535 AAB41536 AAC84161 AAH34867 BAB28206 BAE20893 BAE27605

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca