InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trnp1

Summary

InnateDB Protein

IDBP-627922.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trnp1

Protein Name

TMF1-regulated nuclear protein 1

Synonyms

2300002D11Rik; Trnp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129613

InnateDB Gene

IDBG-195106 (Trnp1)

Protein Structure

UniProt Annotation

Function

DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points. {ECO:0000269PubMed:16792503, ECO:0000269PubMed:23622239}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:23622239}.

Disease Associations

Tissue Specificity

Expressed in brain and kidney (at protein level). Also detected in spleen and intestine. {ECO:0000269PubMed:16792503, ECO:0000269PubMed:23622239}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0021696	cerebellar cortex morphogenesis
GO:0042127	regulation of cell proliferation
GO:0051726	regulation of cell cycle
GO:0061351	neural precursor cell proliferation