Version 5.4
Mus musculus Protein: Ctnnb1
Summary
InnateDB Protein IDBP-627958.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctnnb1
Protein Name catenin (cadherin associated protein), beta 1
Synonyms Bfc; Catnb; Mesc;
Species Mus musculus
Ensembl Protein ENSMUSP00000125763
InnateDB Gene IDBG-205243 (Ctnnb1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 210 experimentally validated interaction(s) in this database.
They are also associated with 377 interaction(s) predicted by orthology.
Experimentally validated
Total 212 [view]
Protein-Protein 182 [view]
Protein-DNA 12 [view]
Protein-RNA 2 [view]
DNA-DNA 16 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 377 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005198 structural molecule activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030331 estrogen receptor binding
GO:0032403 protein complex binding
GO:0035255 ionotropic glutamate receptor binding
GO:0044212 transcription regulatory region DNA binding
GO:0044325 ion channel binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000578 embryonic axis specification
GO:0000904 cell morphogenesis involved in differentiation
GO:0001501 skeletal system development
GO:0001569 patterning of blood vessels
GO:0001570 vasculogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001706 endoderm formation
GO:0001708 cell fate specification
GO:0001709 cell fate determination
GO:0001711 endodermal cell fate commitment
GO:0001764 neuron migration
GO:0001822 kidney development
GO:0001840 neural plate development
GO:0001889 liver development
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002089 lens morphogenesis in camera-type eye
GO:0003136 negative regulation of heart induction by canonical Wnt receptor signaling pathway
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003338 metanephros morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007160 cell-matrix adhesion
GO:0007268 synaptic transmission
GO:0007398 ectoderm development
GO:0007403 glial cell fate determination
GO:0007494 midgut development
GO:0007507 heart development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009948 anterior/posterior axis specification
GO:0009950 dorsal/ventral axis specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0009987 cellular process
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014010 Schwann cell proliferation
GO:0016055 Wnt signaling pathway
GO:0016331 morphogenesis of embryonic epithelium
GO:0016337 single organismal cell-cell adhesion
GO:0021819 layer formation in cerebral cortex
GO:0022009 central nervous system vasculogenesis
GO:0022405 hair cycle process
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030217 T cell differentiation
GO:0030316 osteoclast differentiation
GO:0030324 lung development
GO:0030539 male genitalia development
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0030997 regulation of centriole-centriole cohesion
GO:0031016 pancreas development
GO:0031069 hair follicle morphogenesis
GO:0031641 regulation of myelination
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032355 response to estradiol
GO:0033077 T cell differentiation in thymus
GO:0033234 negative regulation of protein sumoylation
GO:0034097 response to cytokine
GO:0034333 adherens junction assembly
GO:0034394 protein localization to cell surface
GO:0034613 cellular protein localization
GO:0035050 embryonic heart tube development
GO:0035112 genitalia morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0042127 regulation of cell proliferation
GO:0042129 regulation of T cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0042733 embryonic digit morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0043588 skin development
GO:0043627 response to estrogen
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045445 myoblast differentiation
GO:0045453 bone resorption
GO:0045595 regulation of cell differentiation
GO:0045596 negative regulation of cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046686 response to cadmium ion
GO:0048469 cell maturation
GO:0048489 synaptic vesicle transport
GO:0048513 organ development
GO:0048538 thymus development
GO:0048599 oocyte development
GO:0048617 embryonic foregut morphogenesis
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050808 synapse organization
GO:0051145 smooth muscle cell differentiation
GO:0051291 protein heterooligomerization
GO:0060066 oviduct development
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060439 trachea morphogenesis
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060479 lung cell differentiation
GO:0060484 lung-associated mesenchyme development
GO:0060492 lung induction
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060789 hair follicle placode formation
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061154 endothelial tube morphogenesis
GO:0061198 fungiform papilla formation
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0071260 cellular response to mechanical stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071681 cellular response to indole-3-methanol
GO:0072001 renal system development
GO:0072033 renal vesicle formation
GO:0072053 renal inner medulla development
GO:0072054 renal outer medulla development
GO:0072079 nephron tubule formation
GO:0090279 regulation of calcium ion import
GO:1901215 negative regulation of neuron death
GO:2000008 regulation of protein localization to cell surface
GO:2000017 positive regulation of determination of dorsal identity
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005915 zonula adherens
GO:0005916 fascia adherens
GO:0005923 tight junction
GO:0005938 cell cortex
GO:0009898 cytoplasmic side of plasma membrane
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0030018 Z disc
GO:0030027 lamellipodium
GO:0030057 desmosome
GO:0030877 beta-catenin destruction complex
GO:0031253 cell projection membrane
GO:0031528 microvillus membrane
GO:0032993 protein-DNA complex
GO:0043198 dendritic shaft
GO:0043296 apical junction complex
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0070369 beta-catenin-TCF7L2 complex
Protein Structure and Domains
PDB ID MGI:88276
InterPro IPR000225 Armadillo
IPR013284 Beta-catenin
IPR016024 Armadillo-type fold
PFAM PF00514
PRINTS PR01869
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q6A9
UniProt Splice Variant
Entrez Gene 12387
UniGene Mm.291928
RefSeq
MGI ID
MGI Symbol Ctnnb1
OMIM
CCDS
HPRD
IMGT
EMBL AC145731
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca