Version 5.4
Mus musculus Protein: Klf3
Summary
InnateDB Protein IDBP-628141.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klf3
Protein Name Kruppel-like factor 3 (basic)
Synonyms 9930027G08Rik; AL024007; Bklf; Tef-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000129363
InnateDB Gene IDBG-165848 (Klf3)
Protein Structure
UniProt Annotation
Function Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis. {ECO:0000269PubMed:15684403, ECO:0000269PubMed:8657145}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity In 8.5 day embryos, expressed in midbrain, anterior hindbrain and ventral forebrain. In 9 day embryos, expressed throughout ventral anterior half of embryo including midbrain-hindbrain junction, ventral midbrain, diencephalon and forebrain. At 10.5 days, distribution is more widespread with expression also found in developing limb buds. Widely expressed in the adult. {ECO:0000269PubMed:8657145}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:1901653 cellular response to peptide
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1342773
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR029033 Histidine phosphatase superfamily
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60980
PhosphoSite PhosphoSite-Q60980
TrEMBL Q8BV07
UniProt Splice Variant
Entrez Gene 16599
UniGene
RefSeq NP_032479
MGI ID 1U86
MGI Symbol Klf3
OMIM
CCDS CCDS19301
HPRD
IMGT
EMBL AK007959 AK081467 AK143838 BC116938 BC119214 CH466524 DQ981866 U36340
GenPept AAA93256 AAI16939 AAI19215 ABI93805 BAB25371 BAC38227 BAE25562 EDL37721

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca