InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phc3

Summary

InnateDB Protein

IDBP-628197.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phc3

Protein Name

polyhomeotic-like 3 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130142

InnateDB Gene

IDBG-136062 (Phc3)

Protein Structure

UniProt Annotation

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous expression. {ECO:0000269PubMed:12384788}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007275	multicellular organismal development
GO:0008150	biological_process

Cellular Component

GO:0005634	nucleus
GO:0015629	actin cytoskeleton
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:2181434

InterPro

IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR012313 Zinc finger, FCS-type
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CHP6