InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HM13

Summary

InnateDB Protein

IDBP-62952.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HM13

Protein Name

histocompatibility (minor) 13

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000335294

InnateDB Gene

IDBG-62948 (HM13)

Protein Structure

UniProt Annotation

Function

Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. {ECO:0000250, ECO:0000269PubMed:11714810, ECO:0000269PubMed:12077416, ECO:0000269PubMed:12145199, ECO:0000269PubMed:14741365}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.Isoform 4: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla. {ECO:0000269PubMed:12139484, ECO:0000269PubMed:12972007}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving
GO:0042803	protein homodimerization activity

Biological Process

GO:0033619

membrane protein proteolysis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane