InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM41

Summary

InnateDB Protein

IDBP-62973.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM41

Protein Name

tripartite motif containing 41

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000320869

InnateDB Gene

IDBG-62969 (TRIM41)

Protein Structure

UniProt Annotation

Function

Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C. {ECO:0000269PubMed:17893151}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16022281}. Nucleus {ECO:0000269PubMed:16022281}.

Disease Associations

Tissue Specificity

Expressed in multiple tissues with the highest levels in heart and skeletal muscle. {ECO:0000269PubMed:17893151}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0016567

protein ubiquitination

Cellular Component

GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type
IPR022081 Domain of unknown function DUF3631

PFAM