Version 5.4
Homo sapiens Protein: SCAF1
Summary
InnateDB Protein IDBP-63170.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCAF1
Protein Name SR-related CTD-associated factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000353769
InnateDB Gene IDBG-63168 (SCAF1)
Protein Structure
UniProt Annotation
Function May function in pre-mRNA splicing. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in fetal brain and liver, poorly expressed in salivary gland, heart, skin and ovary. Expressed in colorectal carcinomas and ovarian cancers. Overexpressed in colorectal carcinomas as compared to normal colonic mucosa. {ECO:0000269PubMed:11461075, ECO:0000269PubMed:15493872, ECO:0000269PubMed:16631123, ECO:0000269PubMed:17132108}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H7N4
PhosphoSite PhosphoSite-Q9H7N4
TrEMBL M0R3G4
UniProt Splice Variant
Entrez Gene 58506
UniGene Hs.103521
RefSeq NP_067051
HUGO HGNC:30403
OMIM
CCDS CCDS33074
HPRD 11604
IMGT
EMBL AC011495 AF254411 AK024444 BC018398 BC053992
GenPept AAF87552 AAH18398 AAH53992 BAB15734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca