InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P2RY2

Summary

InnateDB Protein

IDBP-63699.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RY2

Protein Name

purinergic receptor P2Y, G-protein coupled, 2

Synonyms

HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R;

Species

Homo sapiens

Ensembl Protein

ENSP00000310305

InnateDB Gene

IDBG-63697 (P2RY2)

Protein Structure

UniProt Annotation

Function

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Spleen, testis, kidney, liver, lung, heart and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0045028	G-protein coupled purinergic nucleotide receptor activity

Biological Process

GO:0006873	cellular ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0042312	regulation of vasodilation
GO:0070257	positive regulation of mucus secretion