InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF473

Summary

InnateDB Protein

IDBP-64046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF473

Protein Name

zinc finger protein 473

Synonyms

HZFP100; ZN473;

Species

Homo sapiens

Ensembl Protein

ENSP00000270617

InnateDB Gene

IDBG-64044 (ZNF473)

Protein Structure

UniProt Annotation

Function

Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases. {ECO:0000269PubMed:11782445, ECO:0000269PubMed:16714279, ECO:0000269PubMed:16914750}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16714279}. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006398	histone mRNA 3'-end processing
GO:0008334	histone mRNA metabolic process
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing