InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXS1

Summary

InnateDB Protein

IDBP-64093.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXS1

Protein Name

forkhead box S1

Synonyms

FKHL18; FREAC10;

Species

Homo sapiens

Ensembl Protein

ENSP00000365145

InnateDB Gene

IDBG-64091 (FOXS1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001568	blood vessel development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0040018	positive regulation of multicellular organism growth
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050885	neuromuscular process controlling balance