Version 5.4
Homo sapiens Protein: PPME1
Summary
InnateDB Protein IDBP-64188.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPME1
Protein Name protein phosphatase methylesterase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000329867
InnateDB Gene IDBG-232998 (PPME1)
Protein Structure
UniProt Annotation
Function Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269PubMed:10318862}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
Experimentally validated
Total 43 [view]
Protein-Protein 42 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0008601 protein phosphatase type 2A regulator activity
GO:0019903 protein phosphatase binding
GO:0051721 protein phosphatase 2A binding
GO:0051722 protein C-terminal methylesterase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006482 protein demethylation
GO:0043086 negative regulation of catalytic activity
GO:0050790 regulation of catalytic activity
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR016812 Protein phosphatase methylesterase, eukaryotic
IPR029058 Alpha/Beta hydrolase fold
PFAM
PRINTS
PIRSF PIRSF022950
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y570
PhosphoSite PhosphoSite-Q9Y570
TrEMBL
UniProt Splice Variant
Entrez Gene 51400
UniGene Hs.674200
RefSeq NP_057231
HUGO HGNC:30178
OMIM 611117
CCDS CCDS44678
HPRD 17864
IMGT
EMBL AF111853 AF157028 AF193049 AK001381 AK022725 AK123288 AP000577 AP002392 BC003046 BC050705 CH471076
GenPept AAD44976 AAF16692 AAG22477 AAH03046 AAH50705 BAA91661 BAC85574 BAG51108 EAW74932

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca