Version 5.4
Homo sapiens Protein: BRI3BP
Summary
InnateDB Protein IDBP-64270.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRI3BP
Protein Name BRI3 binding protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000340761
InnateDB Gene IDBG-64266 (BRI3BP)
Protein Structure
UniProt Annotation
Function Involved in tumorigenesis and may function by stabilizing p53/TP53. {ECO:0000269PubMed:17943721}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000305PubMed:17943721}; Multi-pass membrane protein {ECO:0000305PubMed:17943721}.
Disease Associations
Tissue Specificity Most abundantly expressed in brain, liver and kidney. Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas. {ECO:0000269PubMed:11860200, ECO:0000269PubMed:17943721}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WY22
PhosphoSite PhosphoSite-Q8WY22
TrEMBL
UniProt Splice Variant
Entrez Gene 140707
UniGene Hs.715316
RefSeq NP_542193
HUGO HGNC:14251
OMIM 615627
CCDS CCDS9262
HPRD 09829
IMGT
EMBL AF283671 AF284094 BC034525
GenPept AAH34525 AAL33003 AAL54382

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca