Version 5.4
Homo sapiens Protein: CHRDL2
Summary
InnateDB Protein IDBP-64370.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRDL2
Protein Name chordin-like 2
Synonyms BNF1; CHL2; FKSG37;
Species Homo sapiens
Ensembl Protein ENSP00000263671
InnateDB Gene IDBG-64368 (CHRDL2)
Protein Structure
UniProt Annotation
Function May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. {ECO:0000250, ECO:0000269PubMed:12853144, ECO:0000269PubMed:15094188}.
Subcellular Localization Isoform 1: Secreted {ECO:0000305}.Isoform 2: Secreted {ECO:0000305}.Isoform 3: Cytoplasm {ECO:0000305}.Isoform 4: Cytoplasm {ECO:0000305}.Isoform 5: Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma. {ECO:0000269PubMed:12853144, ECO:0000269PubMed:14660436, ECO:0000269PubMed:15094188}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001503 ossification
GO:0030154 cell differentiation
GO:0051216 cartilage development
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001007 von Willebrand factor, type C
PFAM PF00093
PRINTS
PIRSF
SMART SM00214
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6WN34
PhosphoSite PhosphoSite-Q6WN34
TrEMBL
UniProt Splice Variant
Entrez Gene 25884
UniGene Hs.432379
RefSeq NP_056239
HUGO HGNC:24168
OMIM 613127
CCDS CCDS8234
HPRD 09881
IMGT
EMBL AX140199 AY163868 AY279090 AY279092 AY279093 AY279094 AY358522 BC142623
GenPept AAI42624 AAO31809 AAQ19179 AAQ19181 AAQ19182 AAQ19183 AAQ88886

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca