InnateDB Protein
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IDBP-64452.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMEM8B
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Protein Name
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transmembrane protein 8B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367235
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InnateDB Gene
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IDBG-64450 (TMEM8B)
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Protein Structure
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Function |
May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. {ECO:0000269PubMed:15498789, ECO:0000269PubMed:15723283, ECO:0000269PubMed:17270023, ECO:0000269PubMed:17641538}.
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Subcellular Localization |
Isoform 2: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic reticulum.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003614
Knottin, scorpion toxin-like
IPR021910
Protein of unknown function DUF3522
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PFAM |
PF12036
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PRINTS |
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PIRSF |
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SMART |
SM00505
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TIGRFAMs |
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Modification |
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SwissProt |
A6NDV4
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51754
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UniGene |
Hs.493808
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RefSeq |
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HUGO |
HGNC:21427
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OMIM |
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CCDS |
CCDS6595
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HPRD |
16674
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IMGT |
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EMBL |
AF070572
AF149297
AF188239
AK074844
AL133410
BC041377
BC098265
BC098296
BC099733
CH471071
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GenPept |
AAC28644
AAF34820
AAG29055
AAH98265
AAH98296
AAH99733
BAG52015
CAI10995
CAI10996
EAW58325
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