InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGFBRAP1

Summary

InnateDB Protein

IDBP-64472.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGFBRAP1

Protein Name

transforming growth factor, beta receptor associated protein 1

Synonyms

TRAP-1; TRAP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000258449

InnateDB Gene

IDBG-64470 (TGFBRAP1)

Protein Structure

UniProt Annotation

Function

Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. {ECO:0000269PubMed:11278302, ECO:0000269PubMed:9545258}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11278302}. Note=Colocalizes with TGF-beta receptors in the absence of signaling.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005083	small GTPase regulator activity
GO:0005160	transforming growth factor beta receptor binding
GO:0005515	protein binding
GO:0046332	SMAD binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0016192	vesicle-mediated transport
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
IPR001180 Citron-like
IPR019452 Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1
IPR019453 Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2

PFAM

PF00637
PF00780
PF10366
PF10367

PRINTS

PIRSF

SMART

SM00299
SM00036

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8WUH2