InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MICALL2

Summary

InnateDB Protein

IDBP-6478.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MICALL2

Protein Name

MICAL-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000297508

InnateDB Gene

IDBG-6474 (MICALL2)

Protein Structure

UniProt Annotation

Function

Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Recycling endosome {ECO:0000250}. Cell projection {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017137	Rab GTPase binding
GO:0031005	filamin binding
GO:0042805	actinin binding
GO:0051015	actin filament binding

Biological Process

GO:0030041	actin filament polymerization
GO:0031175	neuron projection development
GO:0031532	actin cytoskeleton reorganization
GO:0032456	endocytic recycling
GO:0034446	substrate adhesion-dependent cell spreading
GO:0070830	tight junction assembly

Cellular Component

GO:0001725	stress fiber
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0032432	actin filament bundle
GO:0043005	neuron projection
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR001781 Zinc finger, LIM-type
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
IPR022735 Domain of unknown function DUF3585

PFAM

PF00307
PF00412
PF11971
PF12130

PRINTS

PIRSF

SMART

SM00033
SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IY33