Version 5.4
Homo sapiens Protein: GDPD5
Summary
InnateDB Protein IDBP-64819.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDPD5
Protein Name glycerophosphodiester phosphodiesterase domain containing 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000337972
InnateDB Gene IDBG-64817 (GDPD5)
Protein Structure
UniProt Annotation
Function Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine.
Subcellular Localization Endomembrane system {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=In a punctate perinuclear pattern. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008081 phosphoric diester hydrolase activity
GO:0008889 glycerophosphodiester phosphodiesterase activity
Biological Process
GO:0006071 glycerol metabolic process
GO:0006629 lipid metabolic process
GO:0021522 spinal cord motor neuron differentiation
GO:0021895 cerebral cortex neuron differentiation
GO:0031175 neuron projection development
GO:0045666 positive regulation of neuron differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0048505 regulation of timing of cell differentiation
Cellular Component
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030426 growth cone
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WTR4
PhosphoSite PhosphoSite-Q8WTR4
TrEMBL E9PJU5
UniProt Splice Variant
Entrez Gene 81544
UniGene Hs.671860
RefSeq NP_110419
HUGO HGNC:28804
OMIM 609632
CCDS CCDS8238
HPRD 15159
IMGT
EMBL AF318351 AF318377 AF451987 AK074848 AK098808 AP002815 AY358477 BC018771 BC033391
GenPept AAH18771 AAH33391 AAL55858 AAL55884 AAP97686 AAQ88841 BAC05418 BAC11242

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca