InnateDB Protein
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IDBP-64958.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MOGAT2
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Protein Name
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monoacylglycerol O-acyltransferase 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000198801
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InnateDB Gene
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IDBG-64956 (MOGAT2)
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Protein Structure
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Function |
Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. {ECO:0000269PubMed:12621063}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:12621063}; Multi-pass membrane protein {ECO:0000269PubMed:12621063}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in liver, small intestine, colon, stomach and kidney. {ECO:0000269PubMed:12621063, ECO:0000269PubMed:12824082}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
0
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
3
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003846
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2-acylglycerol O-acyltransferase activity
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GO:0016407
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acetyltransferase activity
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GO:0016747
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transferase activity, transferring acyl groups other than amino-acyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007130
Diacylglycerol acyltransferase
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PFAM |
PF03982
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3SYC2
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PhosphoSite |
PhosphoSite-Q3SYC2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80168
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UniGene |
Hs.288568
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RefSeq |
NP_079374
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HUGO |
HGNC:23248
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OMIM |
610270
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CCDS |
CCDS8240
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HPRD |
11367
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IMGT |
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EMBL |
AK026297
AK128620
AK291998
AY157608
BC103876
BC103877
BC103878
CH471076
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GenPept |
AAI03877
AAI03878
AAI03879
AAO23672
BAB15436
BAC87534
BAF84687
EAW74983
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