InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGAT2

Summary

InnateDB Protein

IDBP-64995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGAT2

Protein Name

diacylglycerol O-acyltransferase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000228027

InnateDB Gene

IDBG-64993 (DGAT2)

Protein Structure

UniProt Annotation

Function

Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:14521909}; Multi-pass membrane protein {ECO:0000269PubMed:14521909}. Lipid droplet {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. {ECO:0000269PubMed:11481335, ECO:0000269PubMed:14521909}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003846	2-acylglycerol O-acyltransferase activity
GO:0004144	diacylglycerol O-acyltransferase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0042803	protein homodimerization activity
GO:0050252	retinol O-fatty-acyltransferase activity

Biological Process

GO:0006071	glycerol metabolic process
GO:0006644	phospholipid metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0019915	lipid storage
GO:0034383	low-density lipoprotein particle clearance
GO:0035336	long-chain fatty-acyl-CoA metabolic process
GO:0035356	cellular triglyceride homeostasis
GO:0036155	acylglycerol acyl-chain remodeling
GO:0042572	retinol metabolic process
GO:0042632	cholesterol homeostasis
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046339	diacylglycerol metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0055089	fatty acid homeostasis
GO:0060613	fat pad development
GO:0071400	cellular response to oleic acid
GO:0097006	regulation of plasma lipoprotein particle levels

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm