Homo sapiens Protein: RAB18 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-65000.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | RAB18 | ||||||||||||||||||
Protein Name | RAB18, member RAS oncogene family | ||||||||||||||||||
Synonyms | RAB18LI1; WARBM3; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000349415 | ||||||||||||||||||
InnateDB Gene | IDBG-64998 (RAB18) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration. {ECO:0000269PubMed:21473985}. | ||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. | ||||||||||||||||||
Disease Associations | Warburg micro syndrome 3 (WARBM3) [MIM:614222]: A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. {ECO:0000269PubMed:21473985}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | Ubiquitous. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000795
Elongation factor, GTP-binding domain IPR001806 Small GTPase superfamily IPR002041 Ran GTPase IPR003578 Small GTPase superfamily, Rho type IPR003579 Small GTPase superfamily, Rab type IPR005225 Small GTP-binding protein domain IPR006689 Small GTPase superfamily, ARF/SAR type IPR006762 Gtr1/RagA G protein IPR013684 Mitochondrial Rho-like IPR020849 Small GTPase superfamily, Ras type IPR024156 Small GTPase superfamily, ARF type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00009
PF00071 PF00025 PF04670 PF08477 |
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PRINTS |
PR00315
PR00449 PR00627 PR00328 |
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PIRSF | |||||||||||||||||||
SMART |
SM00176
SM00174 SM00175 SM00173 SM00177 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9NP72 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9NP72 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 22931 | ||||||||||||||||||
UniGene | Hs.613682 | ||||||||||||||||||
RefSeq | NP_067075 | ||||||||||||||||||
HUGO | HGNC:14244 | ||||||||||||||||||
OMIM | 602207 | ||||||||||||||||||
CCDS | CCDS7155 | ||||||||||||||||||
HPRD | 03731 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF087860 AF136974 AF137372 AF498950 AJ277145 AJ277146 AJ277147 AJ277148 AJ277149 AK001555 AK223153 AK295443 AL136734 AL138920 AY574034 BC015014 BC029350 BT009840 CH471072 CR533455 | ||||||||||||||||||
GenPept | AAF61433 AAG49435 AAH15014 AAH29350 AAM21098 AAP88842 AAP97170 AAU08232 BAD96873 BAG50939 BAH12069 CAB66668 CAB86486 CAG38486 CAH70590 EAW86054 EAW86055 | ||||||||||||||||||