Homo sapiens Protein: KLK6 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Protein | IDBP-65228.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | KLK6 | ||||||||||||||||||||||||
Protein Name | kallikrein-related peptidase 6 | ||||||||||||||||||||||||
Synonyms | Bssp; hK6; Klk7; PRSS18; PRSS9; SP59; | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Protein | ENSP00000309148 | ||||||||||||||||||||||||
InnateDB Gene | IDBG-65226 (KLK6) | ||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||
Function | Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. {ECO:0000269PubMed:11983703, ECO:0000269PubMed:12878203, ECO:0000269PubMed:12928483, ECO:0000269PubMed:15557757, ECO:0000269PubMed:16321973, ECO:0000269PubMed:16987227}. | ||||||||||||||||||||||||
Subcellular Localization | Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress. | ||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||
Tissue Specificity | In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors. {ECO:0000269PubMed:10997858, ECO:0000269PubMed:11018688, ECO:0000269PubMed:11668196, ECO:0000269PubMed:12928483, ECO:0000269PubMed:16800739}. | ||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||
InterPro |
IPR001254
Peptidase S1 IPR001314 Peptidase S1A, chymotrypsin-type IPR009003 Trypsin-like cysteine/serine peptidase domain IPR015420 Peptidase S1A, nudel |
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PFAM |
PF00089
PF09342 |
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PRINTS |
PR00722
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PIRSF | |||||||||||||||||||||||||
SMART |
SM00020
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TIGRFAMs | |||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | Q92876 | ||||||||||||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||||||||||||
TrEMBL | A0A024R4J8 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 5653 | ||||||||||||||||||||||||
UniGene | Hs.79361 | ||||||||||||||||||||||||
RefSeq | NP_002765 | ||||||||||||||||||||||||
HUGO | HGNC:6367 | ||||||||||||||||||||||||
OMIM | 602652 | ||||||||||||||||||||||||
CCDS | CCDS12811 | ||||||||||||||||||||||||
HPRD | 04037 | ||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AC011483 AF013988 AF149289 AF243527 AK314897 AY318867 AY318868 AY318869 AY318870 BC015525 BT006852 CH471135 D78203 DQ223012 U62801 | ||||||||||||||||||||||||
GenPept | AAB07113 AAB66483 AAD51475 AAG33359 AAH15525 AAP35498 AAP82446 AAP82448 ABB04464 BAA11306 BAG37411 EAW71953 EAW71954 EAW71955 | ||||||||||||||||||||||||