InnateDB Protein
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IDBP-65364.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HELZ
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Protein Name
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helicase with zinc finger
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Synonyms
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DHRC; DRHC; HUMORF5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000351524
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InnateDB Gene
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IDBG-65362 (HELZ)
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Protein Structure
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Function |
May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed predominantly in thymus and brain. Expression is down-regulated in 28 of 95 tested cancer cell lines. {ECO:0000269PubMed:12691822}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
|
Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000571
Zinc finger, CCCH-type
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00642
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PRINTS |
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PIRSF |
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SMART |
SM00356
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TIGRFAMs |
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Modification |
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SwissProt |
P42694
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PhosphoSite |
PhosphoSite-P42694
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TrEMBL |
J3KT20
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UniProt Splice Variant |
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Entrez Gene |
9931
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UniGene |
Hs.607072
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RefSeq |
NP_055692
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HUGO |
HGNC:16878
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OMIM |
606699
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CCDS |
CCDS42374
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HPRD |
10452
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IMGT |
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EMBL |
AC005544
AC007448
BC094881
D29677
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GenPept |
AAH94881
BAA06147
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