InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD33

Summary

InnateDB Protein

IDBP-65739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD33

Protein Name

CD33 molecule

Synonyms

p67; SIGLEC-3; SIGLEC3;

Species

Homo sapiens

Ensembl Protein

ENSP00000262262

InnateDB Gene

IDBG-65737 (CD33)

Protein Structure

UniProt Annotation

Function

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). {ECO:0000269PubMed:10556798, ECO:0000269PubMed:11320212}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Monocytic/myeloid lineage cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008285	negative regulation of cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20138