InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIGLEC8

Summary

InnateDB Protein

IDBP-65957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIGLEC8

Protein Name

sialic acid binding Ig-like lectin 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000321077

InnateDB Gene

IDBG-65955 (SIGLEC8)

Protein Structure

UniProt Annotation

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed specifically on eosinophils.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NYZ4