InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL1B

Summary

InnateDB Protein

IDBP-66521.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1B

Protein Name

interleukin 1, beta

Synonyms

IL-1; IL1-BETA; IL1F2;

Species

Homo sapiens

Ensembl Protein

ENSP00000263341

InnateDB Gene

IDBG-66519 (IL1B)

Protein Structure

UniProt Annotation

Function

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. {ECO:0000269PubMed:3920526}.

Subcellular Localization

Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	29 [view]
Protein-DNA	21 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005149	interleukin-1 receptor binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0001660	fever generation
GO:0001934	positive regulation of protein phosphorylation
GO:0002711	positive regulation of T cell mediated immunity
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007566	embryo implantation
GO:0008285	negative regulation of cell proliferation
GO:0009743	response to carbohydrate
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010628	positive regulation of gene expression
GO:0010829	negative regulation of glucose transport
GO:0014805	smooth muscle adaptation
GO:0019221	cytokine-mediated signaling pathway
GO:0030213	hyaluronan biosynthetic process
GO:0030593	neutrophil chemotaxis
GO:0030730	sequestering of triglyceride
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031622	positive regulation of fever generation
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032308	positive regulation of prostaglandin secretion
GO:0032496	response to lipopolysaccharide
GO:0032611	interleukin-1 beta production
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032755	positive regulation of interleukin-6 production
GO:0032757	positive regulation of interleukin-8 production
GO:0033129	positive regulation of histone phosphorylation
GO:0033198	response to ATP
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0035066	positive regulation of histone acetylation
GO:0035234	ectopic germ cell programmed cell death
GO:0035505	positive regulation of myosin light chain kinase activity
GO:0035690	cellular response to drug
GO:0042102	positive regulation of T cell proliferation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407	negative regulation of MAP kinase activity
GO:0043491	protein kinase B signaling
GO:0045080	positive regulation of chemokine biosynthetic process
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045766	positive regulation of angiogenesis
GO:0045833	negative regulation of lipid metabolic process
GO:0045840	positive regulation of mitosis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0046827	positive regulation of protein export from nucleus
GO:0050796	regulation of insulin secretion
GO:0050900	leukocyte migration
GO:0050995	negative regulation of lipid catabolic process
GO:0050996	positive regulation of lipid catabolic process
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051781	positive regulation of cell division
GO:0060355	positive regulation of cell adhesion molecule production
GO:0060559	positive regulation of calcidiol 1-monooxygenase activity
GO:0070164	negative regulation of adiponectin secretion
GO:0070487	monocyte aggregation
GO:0071260	cellular response to mechanical stimulus
GO:0071310	cellular response to organic substance
GO:0071407	cellular response to organic cyclic compound
GO:0071639	positive regulation of monocyte chemotactic protein-1 production
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0030141	secretory granule
GO:0031982	vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000975 Interleukin-1 family
IPR003294 Interleukin-1 alpha/beta
IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
IPR003502 Interleukin-1 propeptide
IPR008996 Cytokine, IL-1-like
IPR028142 IL-1 family/FGF family

PFAM

PF00340
PF02394

PRINTS

PR00264
PR01357
PR01360
PR00262

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01584