Version 5.4
Homo sapiens Protein: IL36B
Summary
InnateDB Protein IDBP-66723.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL36B
Protein Name interleukin 36, beta
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000328420
InnateDB Gene IDBG-66719 (IL36B)
Protein Structure
UniProt Annotation
Function Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. {ECO:0000269PubMed:16646978, ECO:0000269PubMed:20300079, ECO:0000269PubMed:21242515}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. {ECO:0000269PubMed:20300079, ECO:0000269PubMed:21242515}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005149 interleukin-1 receptor binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000975 Interleukin-1 family
IPR003294 Interleukin-1 alpha/beta
IPR008996 Cytokine, IL-1-like
PFAM PF00340
PRINTS PR00264
PR01357
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZH7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27177
UniGene Hs.278909
RefSeq NP_775270
HUGO HGNC:15564
OMIM 605508
CCDS CCDS2110
HPRD 05694
IMGT
EMBL AC016724 AF200494 AF201833 BC101831 BC101833 BN000002 CH471217 DQ224343
GenPept AAF25213 AAF69250 AAI01832 AAI01834 AAY14989 ABA60896 CAD29876 EAW73615

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca